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An updated review of male subfertility and leydig cell senescence under oxidative stress: Pathophysiology, mechanisms, and emerging antioxidant and nanotherapeutic approaches
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DOI：10.1016/j.tice.2026.103559.png)
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Abstract
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• Oxidative stress is a major molecular trigger of Leydig cell dysfunction. • ROS-provoked senescence compromises steroidogenesis and spermatogenesis. • Stress response pathways integrate redox signaling and Leydig cell survival. • Emerging antioxidant agents enhance testosterone biosynthesis. • Targeting oxidative senescence improves male reproductive outcomes.
Keywords:
Leydig cell senescence
oxidative stress
steroidogenesis
antioxidant agents
nanotherapeutic approaches
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