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Anionic and cationic drug sorption on interpolyelectrolyte complexes
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DOI：10.1016/j.colsurfb.2018.05.071.png)
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Interpolyelectrolyte complexes of chitosan and poly(sodium 4-styrenesulfonate) [NaPSS] were synthesized and obtained in the form of solid particles, with two different sulfonate to aminium molar ratios: 0.7, resulting in particles with positive zeta potential (IPEC+), and 1.4, yielding particles with negative zeta potential (IPEC-). Both particles were characterized as potential drug sorbents using differently charged drugs: sodium cromoglycate (negatively charged), and tetracycline hydrochloride (positively charged). The adsorption isotherm for cromoglycate and tetracycline on IPEC+ was adequately described by the Langmuir model, while the IPEC- sorption of tetracycline followed the Redlich-Peterson isotherm without the occurrence of cromoglycate sorption. The sorption kinetics consisted of two processes, one fast and the other slow, which were correlated to purely surface-related interactions and processes that resulted in diffusion and/or destruction/rearrangement on the particle surface and subsurface, respectively. Charge build up equilibrium and kinetics were also monitored via zeta potential measurements, and the differences between mass drug uptake and particle charging were used to propose adsorption mechanisms for the systems studied in this work.
Keyword:
Chitosan
Poly(sodium 4-styrenesulfonate)
Interpolyelectrolyte complex
Cromoglycate
Tetracycline
Drug upload/release
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