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Antineoplastic and Immunomodulatory Effects of Cabozantinib in Continuous and Primary Human Anaplastic Thyroid Cancer Cells
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DOI：10.3390/cancers18152379.png)
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Abstract
En 中文
Anaplastic thyroid cancer (ATC) is a very aggressive tumor, whose treatment is still a challenge. We aimed to investigate the tyrosine kinase inhibitor cabozantinib (that has been approved for the treatment of locally advanced or metastatic differentiated thyroid cancer) in cell cultures of ATC in an in vitro study. No study in the literature has evaluated the antineoplastic and immunomodulatory effects of cabozantinib in vitro in primary and/or continuous ATC cells. Therefore, we have performed in vitro studies in primary human cells of ATC (pATC) obtained directly from five patients and in two continuous ATC cell lines. It is noteworthy that pATC are able to maintain the features of the original tissues from which they derived therefore allowing a personalization of the therapy. Our results showed a significant antineoplastic activity and an immunomodulatory effect of cabozantinib in both continuous and primary human ATC cells.
Keywords:
anaplastic thyroid cancer
cabozantinib
primary cell cultures
in vitro study
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