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Application of physiologically-based pharmacokinetic modelling to guide oral ketamine prescription in analgesic doses
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DOI：10.1002/bcp.70662.png)
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Abstract
En 中文
This study aimed to apply physiologically based pharmacokinetic (PBPK) models of ketamine (KET) and its active metabolite norketamine (norKET) after oral administration to evaluate appropriate dosing protocols for racemic KET in ethnically diverse adult populations.
Keywords:
dose optimization
ethnic variability
therapeutic drug monitoring
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