Applying ecological principles to microbiome engineering

Lucas P. Henry

doi:10.1038/s41564-025-02076-7

2025-08-05

PRE

Lucas P. Henry *

Joy Bergelson *

DOI：10.1038/s41564-025-02076-7

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摘要

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微生物组工程旨在重塑微生物群落以改善生态系统功能。然而，许多尝试因设计原则不足而失败，通常导致关键微生物的丧失以及工程化群落与其预期功能之间联系的破坏。相比之下，几十年来宏观生态学领域的研究已揭示调控生物多样性与环境功能之间关系的关键原则。本文将这些生态学原则应用于微生物组工程，重点关注三个阶段：微生物组设计、定殖和维持。我们提出新的方法，利用潜在的生态动力学——特别是生态位动力学——来优化多样性和丰度，以促进稳定性和功能性，尤其是在宿主相关微生物组中。我们还强调了将宏观生态系统见解应用于微生物系统的关键研究重点。通过这种方式改进微生物组工程有望解决医学和农业中的紧迫挑战，同时提供关于维持跨生物尺度的生物多样性的生态过程的理解。本述评讨论了将宏观生态系统的生态学原则应用于微生物组工程的应用。作者提出了必要的研究重点，以促进这些生态学原则的应用，从而改善微生物组功能。

期刊

Nature Microbiology

IF:

19.4

论文数:

633

被引数:

2.7W

机构

Center for Genomics and Systems Biology

学者数:

论文数: 4

被引数: 0

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