.png){kind=icon}
返回
Are essential genes really essential?
.png){kind=icon}
PRE
AI
DOI：10.1016/j.tim.2009.08.005.png)
.png){kind=icon}
原文求助.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Gene essentiality has emerged as an often-asked question in the wake of bacterial genome sequencing and a renaissance in studies of prokaryotic physiology. Genome-scale efforts at describing essential gene sets have necessarily been carried out under standard and tractable growth conditions in a laboratory setting. In addition to reinforcing our understanding of core bacterial physiology, these studies have also uncovered large numbers of essential genes encoding proteins whose functions remain poorly described. Studies of these and other elements of core physiology have naturally followed and several paradoxes, relating to growth conditions and genetic context, have begun to challenge our understanding of the term essential gene. Most recently genome-scale genetic interaction studies have revealed remarkable density and redundancy in biological systems with profound implications for dispensability phenotypes associated with single gene mutations. Consequently, the phenotype essential should be carefully viewed as contextual.
Keyword:
GALACTOSE-SENSITIVE MUTANTS
RHIZOBIUM-MELILOTI
ESCHERICHIA-COLI
BACILLUS-SUBTILIS
CELL-WALL
STAPHYLOCOCCUS-AUREUS
PATHOGENICITY ISLAND
E. COLI
SALMONELLA
BIOSYNTHESIS
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
14.9
论文数:
3.9K
被引数:
1.9W
机构
引用论文
.png){kind=icon}
分享收藏分享收藏
查看更多内容