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Arylsulfatase I is a novel lysosomal chondroitin endosulfatase regulating endochondral ossification

delete2026-03-29
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R
Rafaela Grecco-Machado
S
Satomi Nadanaka
Y
Yuko Naito-Matsui
M
Maria Iavazzo
D
Devin S Brown
M
Marziyeh Hassanzadeh
T
Tuanjie Chang
E
Elena Polishchuk
I
Ingrid J. Pickering
G
Graham N. George
M
Mark J. Hackett
N
Nicola Volpi
C
Carmine Settembre
H
Hiroshi Kitagawa
B
B. Frank Eames *
DOI：10.1016/j.matbio.2026.03.005delete
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Abstract

Abstract

En 中文
• XRF imaging showed that proteoglycan sulfation decreases during cartilage maturation • ARSI is expressed where cartilage sulfation decreases • Biochemical analyses show that ARSI is a novel endosulfatase of chondroitin-4-sulfate at acidic pH • ARSI localizes to lysosomes, which are disrupted in Arsi-/- chondrocytes • Maturation markers are upregulated in Arsi-/- chondrocytes
Keywords:
endochondral ossification
cartilage maturation
chondroitin sulfate proteoglycans
XRF imaging
endosulfatase
ARSI
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