.png){kind=icon}
.png){kind=icon}
Return
Association of Right Ventricular-Pulmonary Arterial Coupling and Progression of Tricuspid Regurgitation in Patients With Atrial Fibrillation
.png){kind=icon}
OA
AI
D
S
J
S
S
B
S
S
S
D
S
DOI：10.1161/JAHA.124.037757.png)
.png){kind=icon}
.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Background Tricuspid regurgitation (TR) severity is associated with poor prognosis in patients with atrial fibrillation (AF). Recently, right ventricular-pulmonary arterial (RV-PA) coupling has been shown to be related to clinical outcomes in patients with TR. However, data on the relationship of RV-PA coupling to the progression of significant TR are limited. This study aimed to investigate whether RV-PA coupling affects the progression of significant TR in patients with AF. Methods Among 664 patients with AF who underwent follow-up echocardiography at least 6 months after the initial assessment, 484 consecutive patients with AF (mean age 68 +/- 12 years, 38% women) with insignificant TR were included. RV-PA coupling was assessed by the ratio of RV 4-chamber strain measured through speckle tracking echocardiography to pulmonary artery systolic pressure (PASP). Results Over a mean 3.6 +/- 2.7 years of follow-up, 46 (9.5%) patients have progressed to significant TR, at least a moderate degree. Patients who progressed to significant TR were older, more likely to be women, had higher E/e' and PASP, lower RV4CSL and RV 4-chamber strain /PASP compared with patients without TR progression. RV-PA coupling, reflected by RV 4-chamber strain/PASP, was independently associated with the progression of TR even after adjusting for age, sex, and E/e' (P <0.001). It remained significant for predicting TR progression even after further adjustment for PASP or RV strain (all P <0.001). Conclusions In patients with AF, RV-PA coupling was independently associated with the progression of TR, suggesting that it may be helpful in monitoring this population.
Keywords:
atrial fibrillation
right ventricle
risk factors
valvular heart disease
AI Summary
Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.
Journal
IF:
5.3
Papers:
1.1W
Citations:
4.5W
Organization
Cited Papers