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Associations Among Cognitive Performance, VCAM-1, and GFAP in Black Adults: The ARCHES Study
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DOI：10.1016/j.neurobiolaging.2026.07.003.png)
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Abstract
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• High VCAM-1 strengthens the negative GFAP–PACC association • GFAP relates to lower cognition only when vascular inflammation is elevated • Interaction persists after ADI and APOE ε4 adjustment • Effects appear in PACC but not MoCA • Joint biomarkers may capture early neurovascular dysfunction
Keywords:
VCAM-1
GFAP
PDGFRβ
Black adults
Aging
Cognition
Neurovascular
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