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Astrocyte-mediated angiogenesis in CNS diseases: mechanisms and therapeutic implications

delete2026-05-06
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OA
AI
Z
Zhidong He
Y
Ying Mao
L
Lumei Chi
J
Jing Sun *
DOI:10.1016/j.brainresbull.2026.111914delete
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Abstract

Abstract

En 中文
• Astrocytes exhibit context-dependent dual roles in CNS angiogenesis. • Disease-associated astrocyte subsets replace the binary A1/A2 paradigm. • VEGF shows a temporal dichotomy: acute harmful, subacute beneficial. • Targeting astrocyte subsets offers new strategies for stroke and GBM. • Single-cell and spatial omics are key to translating astrocyte biology.
Keywords:
Astrocytes
Angiogenesis
Neurovascular unit
Ischemic stroke
Glioblastoma
Heterogeneity
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Brain Research Bulletin cover
Brain Research Bulletin
IF:
3.7
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6.8K
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1.2W

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Jilin University
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Papers: 5.5W
Citations: 8.9K
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