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Atroposelective catalysis
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DOI：10.1038/s41570-024-00618-x.png)
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Atropisomeric compounds-stereoisomers that arise from the restricted rotation about a single bond-have attracted widespread attention in recent years due to their immense potential for applications in a variety of fields, including medicinal chemistry, catalysis and molecular nanoscience. This increased interest led to the invention of new molecular motors, the incorporation of atropisomers into drug discovery programmes and a wide range of novel atroposelective reactions, including those that simultaneously control multiple stereogenic axes. A diverse set of synthetic methodologies, which can be grouped into desymmetrizations, (dynamic) kinetic resolutions, cross-coupling reactions and de novo ring formations, is available for the catalyst-controlled stereoselective synthesis of various atropisomer classes. In this Review, we generalize the concepts for the catalyst-controlled stereoselective synthesis of atropisomers within these categories with an emphasis on recent advancements and underdeveloped atropisomeric scaffolds beyond stereogenic C(sp2)-C(sp2) axes. We also discuss more complex systems with multiple stereogenic axes or higher-order stereogenicity. The catalyst-controlled stereoselective synthesis of atropisomers is feasible by four main concepts: desymmetrization, (dynamic) kinetic resolution, direct formation of the stereogenic axis and de novo ring construction. In this Review, pioneering work in atroposelective catalysis is discussed alongside recent advances.
期刊
IF:
51.7
论文数:
1.0K
被引数:
1.6W
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引用论文
Diols Activation by Cu/Borinic Acids Synergistic Catalysis in Atroposelective Ring-Opening of Cyclic DiaryliodoniumsCu/硼酸协同催化活化二醇对环二芳基的选择性开环
PREAI
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Ir-Catalyzed Atroposelective Desymmetrization of Heterobiaryls: Hydroarylation of Vinyl Ethers and Bicycloalkenes红外催化的杂双芳基的选择性去甲基化: 乙烯基醚和双环烯烃的氢芳基化
OAAI
OAAI分享收藏Enantioselective Synthesis of Atropisomers Featuring Pentatomic Heteroaromatics by Pd-Catalyzed C-H Alkynylation.png)
ACS CATALYSIS
ACS CATALYSISIF13.1
PREAI
分享收藏Copper-Catalyzed Asymmetric Ring-Opening of Cyclic Diaryliodonium with Benzylic and Aliphatic Amines
PREAI
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