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Aurora-A regulates MCRS1 function during mitosis
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DOI：10.1080/15384101.2016.1187342.png)
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摘要
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The mitotic spindle is made of microtubules (MTs) nucleated through different pathways involving the centrosomes, the chromosomes or the walls of pre-existing MTs. MCRS1 is a RanGTP target that specifically associates with the chromosome-driven MTs protecting them from MT depolymerases. MCRS1 is also needed for the control of kinetochore fiber (K-fiber) MT minus-ends dynamics in metaphase. Here, we investigated the regulation of MCRS1 activity in M-phase. We show that MCRS1 is phosphorylated by the Aurora-A kinase in mitosis on Ser35/36. Although this phosphorylation has no role on MCRS1 localization to chromosomal MTs and K-fiber minus-ends, we show that it regulates MCRS1 activity in mitosis. We conclude that Aurora-A activity is particularly important in the tuning of K-fiber minus-ends dynamics in mitosis.
Keyword:
Aurora-A kinase
chromosomal microtubules
K-fiber
MCRS1
microtubule minus-end
mitosis
phosphorylation
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A Ran signalling pathway mediated by the mitotic kinase Aurora A in spindle assembly.png)
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