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Automated detection of cerebral microbleeds on ex-vivo MRI scans of community-based older adults

delete2026-05-08
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G
Grant Nikseresht
A
Arnold M. Evia
G
Gady Agam
D
David A. Bennett
J
Julie A. Schneider
K
Konstantinos Arfanakis *
DOI:10.1016/j.neuroimage.2026.121986delete
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Abstract

Abstract

En 中文
• A comprehensive automated detection method for cerebral microbleeds on ex-vivo MRI • Combines synthesis with self-supervised pretraining and confidence-aware learning • Addresses data scarcity and class imbalance • Detects 90% of CMBs at 15 false positives in data from community-based older adults • Partially automates CMB annotation enabling large-scale MRI and pathology studies
Keywords:
magnetic resonance imaging
neuropathology
microbleed
ex-vivo
biomarkers
CMB=cerebral microbleed
CAA=cerebral amyloid angiopathy
AD=Alzheimer’s disease
ICH=intracerebral hemorrhage
SWI=susceptibility weighted imaging
GRE=gradient echo
MAP=Rush Memory and Aging Project
MARS=Minority Aging Research Study
ROS=Religious Orders Study
PMI=post-mortem interval
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Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.

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NeuroImage cover
NeuroImage
IF:
4.5
Papers:
1.3K
Citations:
10.6W

Organization

I
illinois institute of technology
Scholars:
292
Papers: 165
Citations: 0
R
Rush University
Scholars:
1.2W
Papers: 9.7K
Citations: 2.1K
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