.png){kind=icon}
返回
Axonal sensitivity and block dynamics
.png){kind=icon}
PRE
AI
DOI：10.1136/rapm-2024-105950.png)
.png){kind=icon}
原文求助.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
The role of differential nerve block in the development of analgesia after erector spinae plane block has been questioned. While highly myelinated nerves are more sensitive to local anesthetics than unmyelinated ones in vitro, factors influencing drug diffusion, particularly pKa, are more relevant in the clinical setting. Bupivacaine (the drug most used for an 'analgesic' effect) has a relatively high pKa (8.1), and only 15% of it is present in the lipid permeant, unionized form at pH 7.4 so it will penetrate unmyelinated C fibers relatively easily, but the myelin sheaths around other fiber types are a significant barrier to drug diffusion. The greater sensitivity of myelinated axons to local anesthetic action will only be apparent if the drug can reach their membranes in significant concentrations. In the very dynamic situation pertaining to a local anesthetic injection (no matter the site), diffusion factors mean that the concentration of the drug around the axons is likely to be very low and may result in an effect on unmyelinated fibers only.
Keyword:
Analgesia
Anesthesia, Regional
Animal Experimentation
期刊
R
IF:
3.5
论文数:
4.6K
被引数:
7.7K
机构
引用论文
STRUCTURE ACTIVITY RELATIONSHIPS IN DIFFERENTIAL NERVE BLOCK AT HIGH AND LOW-FREQUENCY STIMULATION
OAAI
OAAI分享收藏DIFFERENTIAL SENSITIVITIES OF MAMMALIAN NERVE-FIBERS TO LOCAL-ANESTHETIC AGENTS.png)
ANESTHESIOLOGY
ANESTHESIOLOGYIF9.1
PREAI
分享收藏
分享收藏Differential nerve blockade to explain anterior thoracic analgesia without sensory blockade after an erector spinae plane block may be wishful thinking差异神经阻滞解释竖脊肌平面阻滞后无感觉阻滞的前胸镇痛可能是一厢情愿的想法
PREAI
分享收藏 没有更多内容
没有更多内容