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Binary/Ternary Composites with Applications in Tissue Engineering
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DOI：10.3390/macromol6020026.png)
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摘要
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本研究聚焦于基于聚(ε-己内酯)(PCL)和聚偏氟乙烯(PVDF)的先进复合材料（含或不含银纳米粒子(AgNPs)）的开发与表征，用于周围神经或骨再生。通过将PCL（生物相容性和生物降解性）与PVDF（机械稳定性和压电功能）按不同比例共混，制备了二元(PCL/PVDF)和三元(PCL/PVDF/AgNPs)复合材料。采用绿色合成法制备的AgNPs被引入以增强抗菌活性，并通过改善信号传导支持组织修复。制备了功能性薄膜和静电纺纤维，并采用扫描电子显微镜(SEM)、能量色散X射线光谱(EDX)、傅里叶变换红外光谱(FTIR)、X射线衍射(XRD)和热分析等先进表征技术进行测试。结果表明，材料具有适宜的形貌、化学组成、结构稳定性，并与模拟生理介质发生有利相互作用。初步生物相容性测试证实了良好的细胞活力，支持所设计支架的生物医学应用。总体而言，所得结果突出了AgNPs功能化的PCL/PVDF二元和三元复合材料作为周围神经或骨再生用柔性、耐用、生物活性植入物的潜在应用前景。
Keyword:
poly(epsilon-caprolactone)
poly(vinylidene fluoride)
silver nanoparticles
electrospun fibres
peripheral nerve regeneration
tissue engineering scaffolds
期刊
M
IF:
4.4
论文数:
50
被引数:
0
机构
引用论文
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