.png){kind=icon}
.png){kind=icon}
Return
Bionic intelligent responsive barbed microneedles synergistically remodel the microenvironment for the treatment of refractory pigmentation disorders (melasma)
.png){kind=icon}
OA
AI
H
E
Y
C
Y
X
Y
Y
L
D
Y
C
S
J
DOI：10.1016/j.mtbio.2026.103496.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
• Tick-inspired barbed microneedles ensure robust skin anchoring and deep delivery. • HAMA-PBA matrix ensures ROS-responsive, on-demand release of TXA and ADSC-Exos. • ADSC-Exos uniquely serve as dynamic cross-linkers and potent ROS scavengers. • TXA and ADSC-Exos exert asymmetric synergy to remodel the dermal microenvironment. • This platform achieves unprecedented depigmentation in a severe melasma mouse model.
Keywords:
Biomimetic microneedles
ROS-Responsive biomaterials
Exosomes
Tranexamic acid
Transdermal drug delivery
Hyperpigmentation
Journal
IF:
10.2
Papers:
3.6K
Citations:
9.5K
Organization
Cited Papers