.png){kind=icon}
返回
Biosensing using straight long-range surface plasmon waveguides
.png){kind=icon}
OA
AI
DOI：10.1364/OE.21.000698.png)
.png){kind=icon}
原文求助.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Straight long-range surface plasmon waveguides are demonstrated as biosensors for the detection of cells, proteins and changes in the bulk refractive index of solutions. The sensors consist of 5 mu m wide 22 nm thick Au stripes embedded in polymer (CYTOP (TM)) with microfluidic channels etched into the top cladding. Bulk sensing is demonstrated by sequentially injecting six solutions of different refractive indices in 2 x 10(-3) RIU increments; such index steps were detected with a signal-to-noise ratio of similar to 1000. Selective capture of cells is demonstrated using Au waveguides functionalized with antibodies against blood group A, and red blood cells of group A and O in buffer as positive and negative analyte. Bovine serum albumin in buffer was used to demonstrate protein sensing. A monolayer of bovine serum albumin physisorbed on a carboxyl-terminated self-assembled monolayer on Au was detected with a signal-to-noise ratio of similar to 300. Overall, the biosensor demonstrated a good capability for detecting bulk changes in solution and for sensing analyte over a very wide range of mass (from cells to proteins). The biosensors are compact, inexpensive to fabricate, and may find use over a wide range of cost-sensitive sensing and detection applications. (C) 2013 Optical Society of America
Keyword:
MACH-ZEHNDER INTERFEROMETER
SELF-ASSEMBLED MONOLAYERS
COATED GOLD FEATURES
RESONANCE SENSORS
ELECTROCHEMICAL DIFFERENTIATION
SENSITIVITY
FABRICATION
DESIGN
BSA
SPR
期刊
IF:
3.3
论文数:
6.1W
被引数:
14.3W
机构
引用论文
.png){kind=icon}
分享收藏Integrated optical components utilizing long-range surface plasmon polaritons利用长程表面等离子体激元的集成光学元件OAAI
OAAI分享收藏Comparisons of photopic negative responses elicited by different conditions from glaucomatous eyes
PREAI
分享收藏
查看更多内容