Biosensor-enabled pathway optimization in metabolic engineering

Yuxi Teng

doi:10.1016/j.copbio.2022.102696

2022-06-01

DOI：10.1016/j.copbio.2022.102696

原文链接

查看原文

摘要

En 中文

Microbes can convert inexpensive renewable substrates to valuable metabolites by their natural metabolic pathways. To maximize the productivity, the pathways yet require further optimization, which remains challenging for our limited knowledge of complex biology. Genetically encoded biosensors are able to detect metabolite concentrations or environmental changes and transfer these inputs to measurable or actionable outputs, thus providing enabling regulation and monitoring tools for complicated pathway optimization. Here, we review recent advances in biosensormediated dynamic regulation and strain screening for the highest microbial production of diverse desirable products.

Keyword:

GENETICALLY-ENCODED BIOSENSORS

QUORUM-SENSING CIRCUIT

DYNAMIC CONTROL

GENE-EXPRESSION

ACID PRODUCTION

DESIGN

FLUX

STRATEGIES

REGULATOR

CHEMICALS

AI总结

对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。

期刊

Current Opinion in Biotechnology

IF:

论文数:

5.0K

被引数:

1.9W

机构

university system of georgia

学者数:

7.3W

论文数: 6.6W

被引数: 101

引用论文

Facilities Staffing Requirements for the Veterans Health Administrationâ€"Resource Planning and Methodology for the Future

IF0

2019-08-30

PREAI

Pyruvate-responsive genetic circuits for dynamic control of central metabolism

NATURE CHEMICAL BIOLOGY

IF13.7

2020-09-07

119

PREAI

Xu, Xianhao; Li, Xueliang; Liu, Yanfeng; Zhu, Yonglian; Li, Jianghua; Du, Guocheng; Chen, Jian; Ledesma-Amaro, Rodrigo; Liu, Long

Exploiting nongenetic cell-to-cell variation for enhanced biosynthesis

NATURE CHEMICAL BIOLOGY

IF13.7

2016-03-21

224

PREAI

Xiao, Yi; Bowen, Christopher H.; Liu, Di; Zhang, Fuzhong

Dynamic gene expression engineering as a tool in pathway engineering

CURRENT OPINION IN BIOTECHNOLOGY

IF7

2019-10-01

PREAI

Shen, Xiaolin; Wang, Jia; Li, Chenyi; Yuan, Qipeng; Yan, Yajun

A biosensor-based approach reveals links between efflux pump expression and cell cycle regulation in pleiotropic drug resistance of yeast

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2019-01-01

OAAI

Li, Jian; Kolberg, Kristen; Schlecht, Ulrich; St Onge, Robert P.; Aparicio, Ana Maria; Horecka, Joe; Davis, Ronald W.; Hillenmeyer, Maureen E.; Harvey, Colin J. B.

De novo phenol bioproduction from glucose using biosensor-assisted microbial coculture engineering

BIOTECHNOLOGY AND BIOENGINEERING

IF3.6

2019-09-30

PREAI

Guo, Xiaoyun; Li, Zhenghong; Wang, Xiaonan; Wang, Jing; Chala, Juan; Lu, Yinghua; Zhang, Haoran

A hardware-friendly algorithm for scalable training and deployment of dimensionality reduction models on FPGA

2018 19th International Symposium on Quality Electronic Design (ISQED)

IF0

2018-03-01

OAAI

Mahdi Nazemi; Amir Erfan Eshratifar; Massoud Pedram