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BiRNA-BERT allows efficient RNA language modeling with adaptive tokenization

delete2025-11-20
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OA
AI
M
Md Toki Tahmid
H
Haz Sameen Shahgir
S
Sazan Mahbub
Y
Yue Dong
M
Md. Shamsuzzoha Bayzid *
DOI:10.1038/s42003-025-08982-0delete
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摘要

摘要

En 中文
基于Transformer的模型在生物序列建模中取得了显著成功,但其在RNA上的应用仍受限于序列长度。现有的RNA语言模型通常会对输入进行截断,丢弃对全长任务至关重要的远端核苷酸上下文。此外,先进的NLP分词方法不能直接应用于生物序列,因为在二级结构预测等任务中,核苷酸级别的分辨率是必不可少的。为解决这些挑战,我们提出了BiRNA-BERT,一个在3600万个非编码RNA序列上训练的1.17亿参数Transformer编码器。其核心是一个自适应双分词框架,结合了用于精细结构任务的核苷酸级(NUC)编码和用于高效长序列处理的字节对编码(BPE)。BiRNA-BERT根据输入长度动态选择分词方式,使其能够无截断地处理任意长序列。我们在从短序列分类到长上下文建模和精细核苷酸级RNA结构预测的任务上展示了最佳性能。我们的信息论分析揭示了BPE压缩与NUC分词之间的权衡,并通过实验再次验证了这一点。最后,BiRNA-BERT在固有语言建模性能(通过困惑度和标记恢复衡量)方面表现优异,同时比现有RNA模型更紧凑。代码和模型权重可在 https://github.com/buetnlpbio/BiRNA-BERT 获取。近期研究介绍了BiRNA-BERT,利用自适应双分词技术提升了RNA序列处理和结构预测精度。
Keyword:
RNA language modeling
adaptive dual-tokenization
Transformer encoder
nucleotide-level encoding
byte-pair encoding
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Communications Biology 封面图
Communications Biology
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Bangladesh University of Engineering and Technology
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university of california riverside
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