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Blood–brain barrier permeating dendrimers for alleviation of cerebral ischemia–reperfusion injury
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DOI：10.1016/j.nantod.2026.103115.png)
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Abstract
En 中文
• Controlled synthesis yields monodisperse dendrimers with tailored MW and size. • RONS-triggered deshielding and oxidation enable targeted brain delivery. • PEG deshielding facilitates BBB penetration into cerebral I/R injury lesions. • G4-PB-PEG dendrimer reduces infarct volume and improves neurological outcomes. • Biodegradable components of G4-PB-PEG dendrimer ensure high biocompatibility.
Keywords:
Dendrimer
PEG deshielding
RONS scavenging
Blood–brain barrier
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