Bone-muscle interactions

Hiroshi Kaji

doi:10.1016/j.afos.2025.04.001

2025-05-17

Hiroshi Kaji

DOI：10.1016/j.afos.2025.04.001

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摘要

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骨骼和骨骼肌共同调控运动功能，作为解剖学上相邻的器官协同工作，并通过机械相互作用进行协作。骨骼和肌肉细胞均来源于共同的间充质干细胞。据报道，肌肉组织支持骨折愈合和骨骼修复。共同因素同时影响肌肉和骨骼，而肌少症和骨质疏松症是多种疾病的并发症。过去15年来，关于骨-肌相互作用的研究取得了进展，临床证据证实肌少症和骨质疏松症之间存在关联。多种肌因子或骨因子在骨-肌相互作用中发挥作用，外泌体的参与也已被提出。关于骨-肌相互作用的研究可能转化为肌少症和骨质疏松症治疗的临床应用。

Keyword:

Sarcopenia

Muscle

Bone

Myokine

Osteokine

期刊

Osteoporosis and Sarcopenia

IF:

2.8

论文数:

110

被引数:

320

机构

暂无机构信息

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