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BRD4 binds the nucleosome via both histone and DNA interactions
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DOI：10.1016/j.molcel.2026.07.012.png)
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Abstract
En 中文
• How the BRD4 first bromodomain binds to acetylated nucleosomes is revealed by cryo-EM • BRD4 BD1 presents the histone tail for potential interactions with other proteins • BRD4-S binds with high affinity to both acetylated and unacetylated nucleosomes • Histone H4 acetylation influences the conformation of the BRD4-S/nucleosome complex
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