.png){kind=icon}
.png){kind=icon}
Return
Bringing immunofocusing into focus
.png){kind=icon}
OA
AI
DOI：10.1038/s41541-023-00792-x.png)
.png){kind=icon}
.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Immunofocusing is a strategy to create immunogens that redirect humoral immune responses towards a targeted epitope and away from non-desirable epitopes. Immunofocusing methods often aim to develop universal vaccines that provide broad protection against highly variant viruses such as influenza virus, human immunodeficiency virus (HIV-1), and most recently, severe acute respiratory syndrome coronavirus (SARS-CoV-2). We use existing examples to illustrate five main immunofocusing strategies-cross-strain boosting, mosaic display, protein dissection, epitope scaffolding, and epitope masking. We also discuss obstacles for immunofocusing like immune imprinting. A thorough understanding, advancement, and application of the methods we outline here will enable the design of high-resolution vaccines that protect against future viral outbreaks.
Keywords:
NEUTRALIZING ANTIBODY-RESPONSES
ORIGINAL ANTIGENIC SIN
INFLUENZA-VIRUS HEMAGGLUTININ
CD4 BINDING-SITE
ENVELOPE GLYCOPROTEIN
MONOCLONAL-ANTIBODIES
STRUCTURAL INSIGHTS
IMMUNE-RESPONSE
CELL RESPONSES
V3 LOOP
AI Summary
Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.