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Bronsted Acid-Catalyzed Markovnikov Hydroarylation of Arylcyclobutene: A Route to gem-Diaryl-Substituted Cyclobutanes
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Z
J
Z
鲁
魏
DOI：10.1002/adsc.202400109.png)
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Abstract
En 中文
A regioselective Markovnikov hydroarylation of arylcyclobutene has been developed using Br & oslash;nsted acid catalysis through a protonation/Friedel-Crafts sequence. The metal-free catalytic reaction is operationally simple and feasible compared to previous reports that utilized elaborate arylcyclobutene and specific polyfluorinated reagents, affording a variety of gem-diaryl- substituted arylcyclobutene in good yields. The possible mechanism of the reaction has been explored through step-by-step control experiments. This protocol involving indole in gem-diaryl-substituted cyclobutene scaffolds not only enriches the applications of Br & oslash;nsted acid catalyzed hydroarylation, but also paves the way for a more extensive access to potential bioactive cyclobutanes structures.
Keywords:
Br & oslash
nsted acid catalysis
hydroarylation
cyclobutane
Markovnikov addition
indole
Journal
A
IF:
4
Papers:
1.0W
Citations:
2.6W
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Cited Papers