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C-reactive protein

delete2004-11-01
delete1.3K
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OA
AI
S
Stephen Black
I
Irving Kushner
D
David Samols
DOI：10.1074/jbc.R400025200delete
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摘要

摘要

En 中文
C反应蛋白 (CRP) 是一种在系统发育上高度保守的血浆蛋白，在脊椎动物和许多无脊椎动物中具有同源物，参与对炎症的全身反应。其血浆浓度在炎症状态期间增加，这是长期以来用于临床目的的特征。CRP是一种模式识别分子，与通常在细胞死亡期间暴露或在病原体表面上发现的特定分子构型结合。它在组织损伤或感染后数小时内合成的快速增加表明它有助于宿主防御，并且它是先天免疫反应的一部分。最近，已经认识到轻微CRP升高与未来主要心血管事件之间的关联，从而导致疾病控制中心和美国心脏协会的建议，冠心病中度风险的患者可能会从CRP的测量中受益。这篇综述将主要集中在我们目前对CRP的结构，其配体，与之相互作用的效应分子及其表观功能的理解上。
Keyword:
STREPTOCOCCUS-PNEUMONIAE INFECTION
SYSTEMIC-LUPUS-ERYTHEMATOSUS
AMYLOID-P COMPONENT
FC-GAMMA RECEPTORS
TRANSGENIC MICE
ENDOTHELIAL-CELLS
APOPTOTIC CELLS
C1Q-BINDING SITE
RISK MARKER
COMPLEMENT
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期刊

Journal of Biological Chemistry 封面图
Journal of Biological Chemistry
IF:
3.9
论文数:
11.2W
被引数:
28.3W

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