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CAR-X cell engineering
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DOI：10.1038/s44222-026-00430-w.png)
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Abstract
En 中文
Chimeric antigen receptor (CAR)-T cell therapy has revolutionized the treatment of haematological malignancies and continues to transform the treatment of various other diseases. Nonetheless, current CAR-T cell therapy has limitations that hinder its therapeutic efficacy for expanded applications, some of which might be attributed to intrinsic T cell features. Using immune cells beyond conventional T cells has therefore emerged as a promising strategy to compensate for such limitations. In this Review, we discuss different CAR-engineered immune cells for therapeutic applications by highlighting how unique immune attributes, along with cell-specific manufacturing strategies and CAR designs, address challenges faced by conventional CAR-T cell therapy.
Keywords:
REGULATORY T-CELLS
NATURAL-KILLER-CELLS
TUMOR-ASSOCIATED MACROPHAGES
NK-92 CELLS
NKT CELLS
CD28 COSTIMULATION
EPIGENETIC CHANGES
ANTITUMOR-ACTIVITY
CHIMERIC-RECEPTOR
FOXP3 EXPRESSION