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Carbon-dot nanozyme-empowered responsive hydrogels for smart wound dressing
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DOI：10.1016/j.ces.2025.123225.png)
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Abstract
En 中文
Smart wound dressings that enable real-time monitoring and responsive therapeutic delivery are essential for advancing personalized wound care. In this work, we present a strategy to develop a multifunctional hydrogel patch by embedding carbon dots (C-dots) into an ionically crosslinked sodium alginate (SA) matrix. The C-dots serve dual roles by providing visible, pH-responsive fluorescence for wound monitoring and functioning as superoxide dismutase (SOD)-like nanozymes to scavenge reactive oxygen species (ROS). The patch's optical transparency, pH sensitivity, swelling capacity, and mechanical strength can be tuned by varying the C-dot content. Structural analyses using scanning electron microscopy, Fourier-transform infrared spectroscopy, and synchrotron small-angle X-ray scattering reveal hydrogen bonding between C-dots and alginate chains, which underpins the dual stimuli-responsive behaviors of the developed hydrogel patch. The patch autonomously releases C-dot nanozymes in response to microenvironmental cues and also allows on-demand release upon gentle mechanical pressure, addressing diverse wound care needs. In vitro studies confirm excellent cytocompatibility, enhanced fibroblast proliferation, and protection against ROS-induced damage. This smart, dual-responsive hydrogel patch presents a promising platform for next-generation wound dressings, suitable for chronic wound management and point-of-care wound management.
Keywords:
Carbon dots
Hydrogels
pH sensing
Responsiveness
Wound dressing
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