Carnitine and Depression

doi:10.3389/fnut.2022.853058

2022-03-14

DOI：10.3389/fnut.2022.853058

原文链接

查看原文

摘要

En 中文

Depression has become one of the most common mental diseases in the world, but the understanding of its pathogenesis, diagnosis and treatments remains insufficient. Carnitine is a natural substance that exists in organisms, which can be synthesized in vivo or supplemented by intake. Relationships of carnitine with depression, bipolar disorder and other mental diseases have been reported in different studies. Several studies show that the level of acylcarnitines (ACs) changes significantly in patients with depression compared with healthy controls while the supplementation of acetyl-L-carnitine is beneficial to the treatment of depression. In this review, we aimed to clarify the effects of ACs in depressive patients and to explore whether ACs might be the biomarkers for the diagnosis of depression and provide new ideas to treat depression.

Keyword:

carnitine

acylcarnitines

depression

bipolar disorder

schizophrenia

AI总结

对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。

期刊

Frontiers in Nutrition

IF:

5.1

论文数:

1.4W

被引数:

3.9W

机构

Central South University

学者数:

10.0W

论文数: 7.2W

被引数: 10.9W

引用论文

Isolated pelvic perfusion: plasma pharmacokinetics depend primarily on drug dosage and not the type of drug

Cancer Chemotherapy and Pharmacology

IF0

2005-01-15

PREAI

James F. Belliveau; Elisabeth Arevalo; Hank Griffin; Harold J. Wanebo

Streamflow droughts in the Iberian Peninsula between 1945 and 2005: spatial and temporal patterns

IF0

2012-07-02

OAAI

J. Lorenzo-Lacruz; E. Morán-Tejeda; S. M. Vicente-Serrano; J. I. López-Moreno

Silencing of Genes Flanking the P1 Plasmid Centromere

Science

IF0

1999-01-22

OAAI

Oleg Rodionov; Małgorzata Łobocka; Michael Yarmolinsky

Effects of long-term acetyl-L-carnitine administration in rats: I. Increased dopamine output in mesocorticolimbic areas and protection toward acute stress exposure

NEUROPSYCHOPHARMACOLOGY

IF7.1

2002-09-01

OAAI

Tolu, P; Masi, F; Leggio, B; Scheggi, S; Tagliamonte, A; De Montis, MG; Gambarana, C

Ecological Models and Data in R

IF0

2008-07-01

OAAI

Benjamin M. Bolker

L-carnitine supplementation for the treatment of fatigue and depressed mood in cancer patients with carnitine deficiency - A preliminary analysis 补充左旋肉碱治疗肉碱缺乏的癌症患者乏力和抑郁情绪的初步分析

CARNITINE: THE SCIENCE BEHIND A CONDITIONALLY ESSENTIAL NUTRIENT

IF0

2009-07-08

PREAI

Cruciani, RA; Dvorkin, E; Homel, P; Culliney, B; Malamud, S; Shaiova, L; Fleishman, S; Lapin, J; Klein, E; Lesage, P; Portenoy, R; Estebin-Cruciani, N

L-acetylcarnitine causes rapid antidepressant effects through the epigenetic induction of mGlu2 receptors

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2013-02-04

232

OAAI

Nasca, Carla; Xenos, Dionysios; Barone, Ylenia; Caruso, Alessandra; Scaccianoce, Sergio; Matrisciano, Francesco; Battaglia, Giuseppe; Mathe, Aleksander A.; Pittaluga, Anna; Lionetto, Luana; Simmaco, Maurizio; Nicoletti, Ferdinando

A review of current evidence for acetyl-L-carnitine in the treatment of depression

JOURNAL OF PSYCHIATRIC RESEARCH

IF3.2

2014-06-01

PREAI

Wang, Sheng-Min; Han, Changsu; Lee, Soo-Jung; Patkar, Ashwin A.; Masand, Prakash S.; Pae, Chi-Un

Serum Metabolomic Profiling Based on Fourier Transform-Ion Cyclotron Resonance-Mass Spectrometry: Do the Dysfunctions of Metabolic Pathways Reveal a Universal Risk of Oxidative Stress in Schizophrenia?

ANTIOXIDANTS & REDOX SIGNALING

IF6.1

2020-10-01

PREAI

Cui, Gaoping; Qing, Ying; Hu, Xiaowen; Wang, Pengkun; Sun, Liya; Yang, Xuhan; Jiang, Jie; Zhang, Juan; Wang, Hang; Feng, Lei; Shen, Yuhua; Qin, Shengying; Wan, Chunling

The strength of vicinity annexation in opportunistic networking

2013 Proceedings IEEE INFOCOM

IF0

2013-04-01

OAAI

Tiphaine Phe-Neau; Marcelo Dias de Amorim; Vania Conan

查看更多内容