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Carnosol and melatonin co-treatment attenuates neuroinflammation and oxidative stress in experimental autoimmune encephalomyelitis
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DOI：10.1016/j.biopha.2025.118909.png)
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Abstract
En 中文
• Carnosol and melatonin co-treatment ameliorates EAE clinical signs. • Combination therapy reduces CNS inflammation and enhances remyelination. • Co-treatment synergistically lowers key serum oxidative damage markers. • The combination upregulates Nrf2 and downregulates NF-κB in the spinal cord. • Co-treatment boosts anti-inflammatory IL-10 and liver stress response genes.
Keywords:
Carnosol
Melatonin
Experimental autoimmune encephalomyelitis model
Oxidative stress
Remyelination
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