.png){kind=icon}
.png){kind=icon}
Return
Case Report: longitudinal immunoglobulin abnormalities preceding IgA-λ MGUS and colonic DLBCL: a case suggesting immune-driven B-cell dysregulation
.png){kind=icon}
OA
AI
H
M
G
DOI：10.3389/fonc.2026.1878363.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Monoclonal gammopathy of undetermined significance (MGUS) is a common premalignant condition typically associated with progression to plasma cell disorders. Research suggests that MGUS may also coexist with or precede other lymphoid malignancies; potentially reflecting shared mechanisms involving chronic immune dysregulation. We report a 73-year-old man with more than 10 years of long-standing polyclonal immunoglobulin elevation; who subsequently developed IgA-λ MGUS and was later diagnosed with primary colonic diffuse large B-cell lymphoma (DLBCL). Molecular analysis identified mutations in TET2; IDH2; IGLL5; and DUSP2. Rather than indicating a direct clonal transformation; this case may reflect a multistep process involving chronic immune dysregulation and independent or parallel B-cell clonal events. These findings highlight the potential clinical significance of long-standing immunoglobulin abnormalities and suggest the potential value of longitudinal immune and molecular monitoring.
Keywords:
diffuse large B-cell lymphoma
monoclonal gammopathy
B-cell malignancy
MGUS
primary colonic lymphoma
Journal
IF:
3.3
Papers:
3.4W
Citations:
9.5W
Organization
No organization information available
Cited Papers