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Caspase-8 comes in from the CYLD
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DOI：10.1038/s41418-026-01717-6.png)
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Abstract
En 中文
The lethal effect of injection of the endotoxin, lipopolysaccharide, as a surrogate for sepsis, is known to require both Caspase-8 and Caspase-11 in mice. In this issue, Liu et al. provide compelling evidence that the cleavage of the de-ubiquitinase CYLD by Caspase-8 is required for Caspase-11 expression, thus providing the “missing link” for the role of Caspase-8 in endotoxicity.
Keywords:
Cell biology
Pathogenesis
Life Sciences
general
Biochemistry
Cell Biology
Stem Cells
Apoptosis
Cell Cycle Analysis
Journal
C
IF:
0
Papers:
147
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0
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Cited Papers