Cationic liposome-based silencing of thioredoxin reductase-1 for sensitization of MDA-MB 231 cells to gamma radiation

2025-12-26

PRE

Sandeep B. Shelar *

Manideepa Basu

P.A. Hassan

K.C. Barick *

DOI：10.1016/j.bbamcr.2025.120100

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• Developed biocompatible cationic liposome for intracellular delivery of shTrxRd1. • Discussed a strategy to improve efficacy of radiotherapy in MDA-MB-231 cells. • γ-radiation enhanced ROS generation in TrxRd1 knockdown cancer cells. • TrxRd1 knockdown substantially sensitizes MDA-MB-231 cells by γ-radiation.

Cationic liposome-based silencing of thioredoxin reductase-1 for sensitization of MDA-MB 231 cells to gamma radiation

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