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Cell-drug conjugates
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DOI：10.1038/s41551-024-01230-6.png)
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By combining living cells with therapeutics, cell-drug conjugates can potentiate the functions of both components, particularly for applications in drug delivery and therapy. The conjugates can be designed to persist in the bloodstream, undergo chemotaxis, evade surveillance by the immune system, proliferate, or maintain or transform their cellular phenotypes. In this Review, we discuss strategies for the design of cell-drug conjugates with specific functions, the techniques for their preparation, and their applications in the treatment of cancers, autoimmune diseases and other pathologies. We also discuss the translational challenges and opportunities of this class of drug-delivery systems and therapeutics. This Review discusses strategies for the design of cell-drug conjugates, the techniques for their preparation, and their translational applications, particularly for the treatment of cancers and autoimmune diseases.
Keyword:
NATURAL-KILLER-CELLS
STEM-CELLS
TUMOR-CELLS
SIALIC-ACID
LIFE-SPAN
DELIVERY
SURFACE
NANOPARTICLES
THERAPY
MACROPHAGES
期刊
IF:
26.6
论文数:
1.7K
被引数:
2.0W
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