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Cell sheet engineering

delete2026-08-01
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PRE
AI
M
McKee, Christine C.
J
Joyce Wong *
DOI:10.1038/s44222-026-00437-3delete
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摘要

摘要

En 中文
细胞片工程可实现无支架组织重建,同时保留天然细胞-细胞连接和细胞外基质结构。然而,该技术的临床转化因生产成本高、开源方案有限、监管挑战及功能局限性(尤其是机械稳定性方面)而受阻。本综述首先描述了如何利用刺激响应性基质制备细胞片,并探讨了其在心脏、肝脏、子宫、肌腱、韧带和儿科领域的应用。随后,我们讨论了细胞片工程中的关键机械考量,包括通过片层堆叠调控机械性能的策略、通过微图案化控制各向异性,以及循环机械调节。通过阐述技术革新与遗留挑战,我们为扩展细胞片工程在机械要求苛刻的组织环境中的应用提供了框架。
Keyword:
CONGENITAL HEART-DISEASE
VASCULAR GRAFTS
3-DIMENSIONAL TISSUES
MECHANICAL-PROPERTIES
SELF-ORGANIZATION
TRANSPLANTATION
CULTURE
FABRICATION
RECONSTRUCTION
SURFACES

期刊

N
Nature Reviews Bioengineering
IF:
37.6
论文数:
92
被引数:
0

机构

B
boston university
学者数:
3.8W
论文数: 3.2W
被引数: 67
引用论文

引用论文

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