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Cellular gradient flow structure linking single-cell-level rules and population-level dynamics
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DOI：10.1103/PhysRevResearch.5.L022052.png)
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In multicellular systems, single-cell behaviors should be coordinated consistently with the overall population dynamics and functions. However, the interrelation between single-cell rules and the population-level goal is still elusive. In this work, we reveal that these two levels are naturally connected via a gradient flow structure of heterogeneous cellular populations and that biologically prevalent single-cell rules, such as unidirectional type switching and hierarchical order in types, emerge from this structure. We also demonstrate the gradient flow structure in a standard model of the T-cell immune response. This theoretical framework works as a basis for understanding multicellular dynamics and functions.
Keyword:
STEM-CELL
OPTIMAL TRANSPORT
DIFFERENTIATION
PROLIFERATION
ROBUSTNESS
APOPTOSIS
DISTANCE
SYSTEMS
CD8(+)
期刊
IF:
4.2
论文数:
7.6K
被引数:
2.7W
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引用论文
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