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Cellular systems for epithelial invagination

delete2017-03-27
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Esther J. Pearl
J
Jingjing Li
J
Jeremy Green *
DOI:10.1098/rstb.2015.0526delete
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摘要

摘要

En 中文
Epithelial invagination is a fundamental module of morphogenesis that iteratively occurs to generate the architecture of many parts of a developing organism. By changing the physical properties such as the shape and/or position of a population of cells, invagination drives processes ranging from reconfiguring the entire body axis during gastrulation, to forming the primordia of the eyes, ears and multiple ducts and glands, during organogenesis. The epithelial bending required for invagination is achieved through a variety of mechanisms involving systems of cells. Here we provide an overview of the different mechanisms, some of which can work in combination, and outline the circumstances in which they apply. This article is part of the themed issue 'Systems morphodynamics: understanding the development of tissue hardware'.
Keyword:
epithelial bending
apical constriction
basal relaxation
basal wedging
cellular tractoring
suprabasal intercalation
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期刊

Philosophical Transactions of the Royal Society B-Biological Sciences 封面图
Philosophical Transactions of the Royal Society B-Biological Sciences
IF:
4.7
论文数:
8.7K
被引数:
5.6W

机构

U
university of london
学者数:
21.5W
论文数: 19.7W
被引数: 305
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