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Chicken meat protein hydrolysate as a functional food ingredient: Antioxidant and dual-targeting neuroprotection against Alzheimer's disease via anti-amyloidogenic and anti-inflammatory pathways
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DOI：10.1016/j.jff.2026.107393.png)
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Abstract
En 中文
• Chicken meat protein hydrolysate (CMPH) exhibited strong antioxidants. • CMPH contained 85.51% of short peptides (≤ 1 kDa) with carnosine and anserine. • CMPH at 0.21–1.71 mg/mL protected SH-SY5Y cells against H₂O₂-induced oxidative stress. • CMPH treatment (1.10–2.20 g/kg) improved spatial memory in Alzheimer's disease model. • Dual-targeting: modulated APP/BACE1/PS1 and reduced TNF-α/NF-κB expression.
Keywords:
Chicken meat protein hydrolysate
Bioactive peptides
Antioxidant activity
Neuroprotection
Functional food
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