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Chiral Cinchona Alkaloid-Thiourea Catalyzed Mannich Reaction for Enantioselective Synthesis of ß-Amino Ketones Bearing Benzothiazol Moiety
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DOI：10.1002/cjoc.201180413.png)
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Abstract
En 中文
Mannich reactions of imine with acetylacetone were effectively catalyzed by the modified chiral cinchona alkaloid-derived thiourea. The reactions led to chiral beta-amino carbonyl compounds in high yields and good enantioselectivities. The study demonstrated for the first time that Mannich reactions of unmodified acetylacetone with heterocyclic imine derived from benzothiazole can be promoted by chiral bifunctional organocatalyst.
Keywords:
asymmetric addition
ss-amino ketones
Mannich reaction
chiral cinchona alkaloid-derived thiourea
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