Choroid Plexus Pathophysiology

Ya’el Courtney

doi:10.1146/annurev-pathmechdis-051222-114051

2025-01-24

PRE

Ya’el Courtney

Alexandra Hochstetler

Maria K. Lehtinen *

DOI：10.1146/annurev-pathmechdis-051222-114051

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摘要

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本综述探讨了脉络丛（ChP）在中央神经系统（CNS）病理学中的作用，强调其在疾病机制中的参与及治疗潜力。已有病例报告和描述性研究报道了人类ChP在不同疾病中的结构变化，但研究尚未明确这些变化的生理相关性。我们重点阐述了ChP的主要病理学表现，以及其在神经疾病中的意义，包括卒中、脑积水、感染性疾病和神经退行性变。综合近期研究，本综述将ChP定位为CNS稳态和病理过程中的关键参与者，倡导加强对ChP机制的研究以解锁新的诊断和治疗策略，最终改善CNS疾病患者的预后。无论ChP是作为疾病的主要驱动因素、病原体进入CNS的门户，还是神经免疫过程的调控者，它都作为极具潜力的治疗靶点，有望减轻多种CNS疾病。

Keyword:

choroid plexus neoplasm

blood-brain barrier

cerebrospinal fluid

hydrocephalus

brain disease

neuroimmunomodulation

期刊

Annual Review of Pathology and Mechanisms of Disease

IF:

34.5

论文数:

392

被引数:

9.5K

机构

Harvard Med Sch

学者数:

238

论文数: 114

被引数: 31

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