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CHRNA5 orchestrates tumorigenesis and immune invasion through the CaMKII/AKT/NF-κB–CCL20 axis in pancreatic ductal adenocarcinoma
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DOI：10.1016/j.lfs.2026.124610.png)
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Abstract
En 中文
• CHRNA5 is identified as the key cholinergic receptor driving PDAC progression. • CHRNA5 silencing suppresses tumor growth and reshapes the microenvironment. • CHRNA5 converts “hot” PDAC tumors into “cold” via CaMKII/AKT/NF-κB-CCL20 axis.
Keywords:
PDAC
,
pancreatic ductal adenocarcinoma
OS
,
overall survival
PNI
,
perineural invasion
ACh
,
acetylcholine
NE
,
norepinephrine
EMT
,
epithelial-mesenchymal transition
CHRNA5
,
cholinergic receptor nicotinic alpha 5
DEGs
,
differentially expressed genes
KEGG
,
Kyoto Encyclopedia of Genes and Genomes
GO
,
Gene Ontology
GSEA
,
Gene Set Enrichment Analysis
FBS
,
fetal bovine serum
DMEM
,
Dulbecco's modified Eagle's medium
SPF
,
specific pathogen-free
LGBM
,
LightGBM
RF
,
Random Forest
MCC
,
Matthews correlation coefficient
AUC
,
area under the receiver operating characteristic curve
SHAP
,
SHapley Additive exPlanations
EGF
,
epidermal growth factor
bFGF
,
basic fibroblast growth factor
BSA
,
bovine serum albumin
DAB
,
3,3′-diaminobenzidine
CSC
,
cancer stem cell
CAM
,
calmodulin
CaMKII
,
calcium-calmodulin CaM-dependent protein kinase II
TIR
,
tumor inhibition rate
HCC
,
hepatocellular carcinoma
ICC
,
intrahepatic cholangiocarcinoma
GEO
,
Gene Expression Omnibus
IFN-γ
,
interferon-gamma
CHRM1
,
cholinergic receptor muscarinic 1
CHRNA5
tumor immune microenvironment
tumor malignancy
PDAC
ACh
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