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Chromatin replication and epigenetic cell memory
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DOI：10.1038/s41556-020-0487-y.png)
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摘要
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Propagation of the chromatin landscape across cell divisions is central to epigenetic cell memory. Mechanistic analysis of the interplay between DNA replication, the cell cycle, and the epigenome has provided insights into replication-coupled chromatin assembly and post-replicative chromatin maintenance. These breakthroughs are critical for defining how proliferation impacts the epigenome during cell identity changes in development and disease. Here we review these findings in the broader context of epigenetic inheritance across mitotic cell division. Groth and colleagues discuss recent advances in chromatin replication and maintenance across mitotic division, with emphasis on replication-coupled chromatin assembly and chromatin maturation post-replication.
Keyword:
LAGGING-STRAND SYNTHESIS
EUKARYOTIC CMG HELICASE
DNA-REPLICATION
HISTONE H3-H4
NASCENT DNA
NUCLEOSOME SEGREGATION
TRANSCRIPTION FACTORS
INHERITANCE
DYNAMICS
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19.1
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