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Chronic Chagas disease and type 2 diabetes comorbidity. The scenario in which two differently driven inflammatory mechanisms meet

delete2026-05-02
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PRE
AI
B
Brenda Dinatale
F
Florencia Belén González
O
Oscar Adelmo Bottasso
A
Ana Rosa Pérez *
DOI：10.1016/j.smim.2026.102028delete
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Abstract

Abstract

En 中文
• Chagas disease and type 2 diabetes share chronic inflammatory pathways. • Persistent T. cruzi infection promotes metabolic and immune-endocrine imbalance. • Metaflammation in T2D amplifies immune exhaustion and tissue injury. • Coexistence of ChD and T2D accelerates metabolic toxicity and immunosenescence. • Understanding this interplay reveals shared therapeutic targets and mechanisms.
Keywords:
Chagas disease
type 2 diabetes
metaflammation
immune exhaustion
immunosenescence

Journal

Seminars in Immunology cover
Seminars in Immunology
IF:
7.8
Papers:
1.5K
Citations:
7.3K

Organization

C
conicet and unr
Scholars:
16
Papers: 6
Citations: 0
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