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Chronic exposure to chlorate at regulatory safety limits induces p21/p16-mediated neuronal senescence and Parkinsonian-like decline

delete2026-08-07
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PRE
AI
C
Cai-Jhen Wu
C
Chien-Tai Hong
J
Jiun-Lin Horng
H
Hung-Shao Lai
H
Hao-Yu Tsai
T
Tsorng-Harn Fong
C
Chen-Yuan Hsiao
C
Cheng-Ying Chu
Y
Yvonne Jing Mei Liew
T
Tien‐Chun Yang *
DOI：10.1016/j.envpol.2026.128929delete
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Abstract

Abstract

En 中文
• Chronic exposure to chlorate induces neuronal senescence at regulatory safety limits. • Sub-cytotoxic exposure activates p21/p16-mediated aging in human iPSC-derived DAn. • Chronic chlorate triggers functional senescence in vivo preceding overt neuronal loss. • Redox stress intensity shifts cellular response from senescence to acute apoptosis. • p21 serves as a redox-sensitive sentinel biomarker for waterborne neurotoxicity.

Journal

Environmental Pollution cover
Environmental Pollution
IF:
7.3
Papers:
2.6W
Citations:
13.8W

Organization

U
universiti malaya
Scholars:
3.5K
Papers: 1.5K
Citations: 0
T
taipei medical university
Scholars:
1.4W
Papers: 1.2W
Citations: 11
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