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Cigarette smoke - an aging accelerator?
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DOI：10.1016/j.exger.2006.09.016.png)
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摘要
En 中文
Cigarette smoking reduces life span by an average of 7 years, and tobacco consumption accounts for a shortening of disease free life by 14 years. The exact mechanisms by which smoking causes disease and death are generally not well understood, but evidence continues to mount that cigarette smoking exhausts cellular defense and repair functions, leading to an accumulation of damage e.g. mutations and malfunctioning proteins. In this review, we make an attempt to ascribe many of the deleterious effects of smoking on human health to a general principle, namely the acceleration of aging processes by cigarette smoke chemicals. (c) 2006 Elsevier Inc. All rights reserved.
Keyword:
senescence
extrinsic aging
intrinsic aging
smoking
cigarette smoke
tobacco
cardiovascular
endothelial
oxidants
radicals
mutagens
osteoporosis
cancer
skin
in vitro
pre-mature
cellular
aging
ageing
