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Circulating tissue factor and thrombosis

delete2000-09-01
delete112
PRE
AI
U
Ursula Rauch
Y
Yale Nemerson
DOI：10.1097/00062752-200009000-00003delete
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摘要

摘要

En 中文
Tissue factor (TF) on circulating microparticles has recently received much attention as a factor in myocardial infarction. We have developed systems by which we have been able to investigate the thrombogenic potential of blood-borne TF. Thrombi develop when native human blood is passed over either collagen-coated glass slides or over pig arterial media. These thrombi immunostain for TF even when the substrate contains none. Moreover, we have demonstrated that the deposited TF is active because the thrombi contain fibrin; fibrin deposition and thrombotic mass are both inhibited by the inclusion of a potent TF-inhibitor in the perfusions. We have also shown that leukocyte-derived particles attach to platelets in a reaction mediated by adhesion proteins. (C) 2000 Lippincott Williams & Wilkins, Inc.
Keyword:
DISSEMINATED INTRAVASCULAR COAGULATION
HUMAN ATHEROSCLEROTIC PLAQUES
SHED MEMBRANE MICROPARTICLES
FACTOR PROCOAGULANT ACTIVITY
FACTOR PATHWAY INHIBITOR
ARTERIAL THROMBOSIS
CELL-ADHESION
FACTOR VIIA
P-SELECTIN
ELEVATED LEVELS
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Current Opinion in Hematology 封面图
Current Opinion in Hematology
IF:
2.9
论文数:
1.7K
被引数:
2.8K

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