Cis-regulatory elements at cellular resolution

Yi Xiang See

doi:10.1038/s41576-025-00882-7

2025-09-16

PRE

Yi Xiang See

Tim Stuart

Jay W. Shin *

DOI：10.1038/s41576-025-00882-7

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近期单细胞分析技术的最新进展，现已能够实现对顺式调控元件活性在多种细胞类型、疾病状态和遗传背景下的常规化与规模化测量。现在是时候协调一项全球性努力，以在单细胞分辨率下系统地绘制顺式调控元件的功能。在本篇评论中，作者概述了在单细胞分辨率下增进我们对顺式调控元件理解的一些关键后续步骤，其中包括协调全球努力以构建一个全面的基因调控单细胞图谱。

Keyword:

cis-regulatory elements

single-cell profiling

gene regulation

cellular resolution

regulatory atlas

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Nature Reviews Genetics

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