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Classification; functions; evolution; and applications of defective viral genomes
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DOI：10.3389/fmicb.2026.1921324.png)
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Abstract
En 中文
Defective viral genomes (DVGs) are truncated or rearranged products derived from parental viruses during replication and they harbour numerous lethal mutations or large-fragment deletions. Current studies have demonstrated that DVGs play crucial roles in interfering with normal viral replication and activating host innate immunity; suggesting that the presence of DVGs not only may modulate the course of viral infection but also holds substantial potential for applications in antiviral drugs and immune adjuvants. Nevertheless; the mechanisms underlying the functions of different types of DVGs remain incompletely elucidated; thus emphasising the necessity of updating analytical and research methodologies. Consequently; while summarizing the core functions; mechanisms of action; and the evolution of DVGs; this review provides a detailed overview of their classification methods to shed light on the characteristics of DVG formation and functions. In addition; it reviews the current detection technologies of DVGs to enable the identification and accurate quantification of DVGs. Furthermore; the discussion encompasses the distinctive mechanisms of action and the potential applications of DVGs derived from diverse viruses; with the objective of providing novel insights into the development of clinical antiviral drugs.
Keywords:
vector
evolution
antiviral drugs
vaccine adjuvants
defective viral genomes
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4.5
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4.0W
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16.6W
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Cited Papers