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Clathrin assemblies at a glance
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DOI：10.1242/jcs.261674.png)
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Clathrin assembles into honeycomb-like lattices at the plasma membrane but also on internal membranes, such as at the Golgi and tubular endosomes. Clathrin assemblies primarily regulate the intracellular trafficking of different cargoes, but clathrin also has nonendocytic functions in cell adhesion through interactions with specific integrins, contributes to intraluminal vesicle formation by forming flat bilayered coats on endosomes and even assembles on kinetochore k-fibers during mitosis. In this Cell Science at a Glance article and the accompanying poster, we review our current knowledge on the different types of canonical and non-canonical membrane-associated clathrin assemblies in mammalian cells, as observed by thin-section or platinum replica electron microscopy in various cell types, and discuss how the structural plasticity of clathrin contributes to its functional diversity.
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KEY WORDS
Clathrin
Electron microscopy
Endocytosis
Endosome
Plasma membrane
Trans-Golgi network
期刊
IF:
3.6
论文数:
1.1W
被引数:
3.7W
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引用论文
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