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Clinical Characteristics and Prognostic Impact of Multiple Pathogenic Variants Across the Genetic Spectrum of Arrhythmogenic and Dilated Cardiomyopathies
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DOI：10.1016/j.hrthm.2026.07.051.png)
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Abstract
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Arrhythmogenic and dilated cardiomyopathies (ACM/DCM) are genetically heterogenous disorders of the right and/or left ventricle associated with an increased risk of major arrhythmic events (MAE) and end-stage heart failure (ESHF). In arrhythmogenic right ventricular cardiomyopathy (ARVC), the presence of >1 pathogenic/likely pathogenic (P/LP) variant is associated with worse outcomes. Whether this phenomenon occurs for non-desmosomal arrhythmogenic left ventricular cardiomyopathy (ALVC)/DCM genes is unknown.
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