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Clinical Significance of Peripheral Blood Lymphocyte Subsets and Cytokine Profiles in Patients with Respiratory Syncytial Virus Infection
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PRE
AI
M
X
J
汪
M
B
W
DOI：10.1016/j.micinf.2025.105583.png)
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Abstract
En 中文
This study characterizes the alterations in peripheral blood lymphocyte subsets and cytokine levels in patients with respiratory syncytial virus (RSV) infection and evaluates their clinical relevance. We collected clinical data from 215 RSV-positive inpatients. Patients were stratified into distinct groups according to different criteria; within-group comparisons were performed. In the RSV-infected group, absolute counts of all peripheral blood lymphocyte subsets were significantly lower than in controls and showed a negative correlation with disease severity. Conversely, all measured cytokines were markedly elevated in the infected group and positively correlated with the severity of RSV infection. Within the infected group, elderly patients (≥65 years) showed significantly different lymphocyte-subset counts and cytokine profiles compared with non-elderly patients. Similarly, individuals with high-risk diseases exhibited significant differences in these parameters relative to those without such diseases. RSV infection induces abnormalities in peripheral blood lymphocyte subsets and cytokine levels. The magnitude of these immune changes is linked to disease severity, patient age, and selected comorbidities, suggesting their potential utility as adjunct biomarkers for clinical assessment.
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